Correlative single photon emission computed tomography imaging of [123I]altropane binding in the rat model of Parkinson's.
Identifieur interne : 001698 ( Main/Exploration ); précédent : 001697; suivant : 001699Correlative single photon emission computed tomography imaging of [123I]altropane binding in the rat model of Parkinson's.
Auteurs : Jacqueline A. Gleave [Canada] ; Troy H. Farncombe ; Chantal Saab ; Laurie C. DoeringSource :
- Nuclear medicine and biology [ 1872-9614 ] ; 2011.
English descriptors
- KwdEn :
- Animals, Behavior, Animal (drug effects), Biomarkers (metabolism), Cocaine (analogs & derivatives), Cocaine (metabolism), Disease Models, Animal, Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins (metabolism), Iodine Radioisotopes, Neostriatum (diagnostic imaging), Neostriatum (drug effects), Neostriatum (metabolism), Neural Stem Cells (transplantation), Oxidopamine (pharmacology), Parkinson Disease (diagnostic imaging), Parkinson Disease (etiology), Parkinson Disease (metabolism), Parkinson Disease (pathology), Rats, Rats, Sprague-Dawley, Stem Cell Transplantation, Tomography, Emission-Computed, Single-Photon.
- MESH :
- chemical , analogs & derivatives : Cocaine.
- chemical , metabolism : Biomarkers, Cocaine, Dopamine, Dopamine Plasma Membrane Transport Proteins.
- diagnostic imaging : Neostriatum, Parkinson Disease.
- drug effects : Behavior, Animal, Neostriatum.
- etiology : Parkinson Disease.
- metabolism : Neostriatum, Parkinson Disease.
- pathology : Parkinson Disease.
- chemical , pharmacology : Oxidopamine.
- transplantation : Neural Stem Cells.
- Animals, Disease Models, Animal, Iodine Radioisotopes, Rats, Rats, Sprague-Dawley, Stem Cell Transplantation, Tomography, Emission-Computed, Single-Photon.
Abstract
This study used the dopamine transporter (DAT) probe, [(123)I]-2β-carbomethoxy-3β-(4-fluorophenyl)-N-(3-iodo-E-allyl)nortropane ([(123)I]altropane), to assess the DAT levels in the 6-hydroxydopamine rat model of Parkinson's disease. We sought to assess if the right to left [(123)I]altropane striatal ratios correlated with dopamine content in the striatum and substantia nigra and with behavioural outcomes.
DOI: 10.1016/j.nucmedbio.2010.12.006
PubMed: 21718949
Affiliations:
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Le document en format XML
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Gleave</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5.</nlm:affiliation><country>Canada</country><wicri:regionArea>Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Farncombe, Troy H" sort="Farncombe, Troy H" uniqKey="Farncombe T" first="Troy H" last="Farncombe">Troy H. Farncombe</name></author><author><name sortKey="Saab, Chantal" sort="Saab, Chantal" uniqKey="Saab C" first="Chantal" last="Saab">Chantal Saab</name></author><author><name sortKey="Doering, Laurie C" sort="Doering, Laurie C" uniqKey="Doering L" first="Laurie C" last="Doering">Laurie C. 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Gleave</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5.</nlm:affiliation><country>Canada</country><wicri:regionArea>Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Farncombe, Troy H" sort="Farncombe, Troy H" uniqKey="Farncombe T" first="Troy H" last="Farncombe">Troy H. Farncombe</name></author><author><name sortKey="Saab, Chantal" sort="Saab, Chantal" uniqKey="Saab C" first="Chantal" last="Saab">Chantal Saab</name></author><author><name sortKey="Doering, Laurie C" sort="Doering, Laurie C" uniqKey="Doering L" first="Laurie C" last="Doering">Laurie C. Doering</name></author></analytic><series><title level="j">Nuclear medicine and biology</title><idno type="eISSN">1872-9614</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Behavior, Animal (drug effects)</term><term>Biomarkers (metabolism)</term><term>Cocaine (analogs & derivatives)</term><term>Cocaine (metabolism)</term><term>Disease Models, Animal</term><term>Dopamine (metabolism)</term><term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term><term>Iodine Radioisotopes</term><term>Neostriatum (diagnostic imaging)</term><term>Neostriatum (drug effects)</term><term>Neostriatum (metabolism)</term><term>Neural Stem Cells (transplantation)</term><term>Oxidopamine (pharmacology)</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Stem Cell Transplantation</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Cocaine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term><term>Cocaine</term><term>Dopamine</term><term>Dopamine Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Neostriatum</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Behavior, Animal</term><term>Neostriatum</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neostriatum</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Oxidopamine</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Neural Stem Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Iodine Radioisotopes</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Stem Cell Transplantation</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study used the dopamine transporter (DAT) probe, [(123)I]-2β-carbomethoxy-3β-(4-fluorophenyl)-N-(3-iodo-E-allyl)nortropane ([(123)I]altropane), to assess the DAT levels in the 6-hydroxydopamine rat model of Parkinson's disease. We sought to assess if the right to left [(123)I]altropane striatal ratios correlated with dopamine content in the striatum and substantia nigra and with behavioural outcomes.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Hamilton (Ontario)</li></settlement><orgName><li>Université McMaster</li></orgName></list><tree><noCountry><name sortKey="Doering, Laurie C" sort="Doering, Laurie C" uniqKey="Doering L" first="Laurie C" last="Doering">Laurie C. Doering</name><name sortKey="Farncombe, Troy H" sort="Farncombe, Troy H" uniqKey="Farncombe T" first="Troy H" last="Farncombe">Troy H. Farncombe</name><name sortKey="Saab, Chantal" sort="Saab, Chantal" uniqKey="Saab C" first="Chantal" last="Saab">Chantal Saab</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Gleave, Jacqueline A" sort="Gleave, Jacqueline A" uniqKey="Gleave J" first="Jacqueline A" last="Gleave">Jacqueline A. 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